Abstract

ANTIBACTERIAL ACTIVITY OF AN ISOLATED COMPOUND (AV-1) FROM THE LEAVES OF TITEYPATI (Artemisia vulgaris Linn.)

*Prasanta Kumar Mitra

Abstract

Antibacterial activity of an isolated compound (AV-1) from the leaves of Titeypati (Artemisia vulgaris Linn.) was evaluated against four Gram-negative bacteria viz.Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli and Shigelladysenteriaas well asfour Gram - positive bacteriaviz. Bacillus megaterium, Staphylococcus aureus, Bacillussubtilis, and Streptococcus pyogenes. Disc diffusion technique was used for in vitro antibacterial screening. Result showed that compound AV-1 had large zone of inhibition in disc diffusion against the said bacteria. Antibacterial activity was more in Gram - positive bacteria than Gram - negative bacteria. Highest activity was noted against Bacillussubtilis and lowest was found for Salmonella typhi.The MIC (minimum inhibitory concentration) values of AV-1 against the bacteria ranged from 4 – 32 microgram/ml. Results, thus, suggest thatthe compound (AV-1) isolated from the leaves of Artemisia vulgaris Linn.had good anti bacterial activity against the tested bacteria.

Keywords: Antibacterial activity, Artemisia vulgaris Linn., Disc diffusion technique, Zone of inhibition, Minimum inhibitory concentration