Abstract

A THERAPEUTIC JOURNEY OF SULFONAMIDE DERIVATIVES AS POTENT ANTI-CANCER AGENTS: A REVIEW

Ali Irfan*, Fozia Batool, Shamsha Irum, Sami Ullah, Muhammad Umer, Rabia Shaheen and Amar Jeet Chand

Abstract

Sulfonamide moiety is a core part of many clinical drugs which have broad spectrum applications in the fields of medicine, pharmacology and pharmaceutics such as antibacterial, antiviral, antifungal, antiinflammatory, anti-carbonic anhydrase, diuretic, protease inhibitor, anti-diabetic, anti-cancer, anti-epileptic drug, cyclooxygenase-2- inhibitor, anticonvulsant, receptor tyrosine kinase inhibitors, antitumor and antipsychotic sulpiride etc. This review article focuses on the role of different sulfonamide scaffolds in the treatment of lethal cancer disease on the basis of structure-activity relationship (SAR). The analogs, scaffolds and combinatorial libraries of sulfonamide mentioned in this plethora of research is very helpful for drug discovery and development of novel anticancer therapeutic agents.

Keywords: Sulfonamide derivatives, Anti-cancer, anti-tumor, Pyrimidine, Pyridin, Thiazole, Carbazole.