Abstract

PREVALENCE OF blaTEM and qnr GENES IN CLINICAL ISOLATES OF PROTEUS VULGARIS FROM PATIENTS WITH URINARY TRACT INFECTION, BABIL, IRAQ

Ghaidaa J. Mohammed*,Mohammed S. Abdul-Razaq, Abdallah K. Hindi and Yanchang Wang

Abstract

Proteus vulgaris resistant to beta-lactam and quinolone drugs, is widely recognized as an opportunistic pathogen causing urinary tract and septic infections; often nosocomial. The resistance property is obtained by acquisition of mobile element-encoded blaTEM and qnr genes. The aim of this study was to document the prevalence of these resistant genes in Proteus vulgaris.The susceptibility of isolates to a variety of antibiotics has been investigated. It has been found that all the isolates had the highest percentage of resistance (100%) to ampicillin, amoxicillin, cephalothin, chloramphenicol and ceftazidime, and some isolates had lower frequencies of resistance to ceftriaxone (89%), ciprofloxacin (82%) and cotrimazole (92.8%).Whereas, all the isolates were sensitive (100%) to amikacin, gentamycin, nitrofurantion,imipenem, meropenem, and norfloxacin. blaTEM and qnr genes were detected in 100% and 50% of isolates, respectively. The results suggest the spread of resistance genes among strains of Proteus vulgaris.

Keywords: Proteus vulgaris, bla Tem gene,qnr gene.