Abstract

ROLE OF AMARANTHUS SPINOSUS LINN. IN INDOMETHACIN INDUCED GASTRIC ULCER IN RATS

Debiprasad Ghosh, Prasenjit Mitra,Tanaya Ghosh, Ravindernath Salhan ,
TakhelmayumAmumacha Singh, Amit Chakrabarti and Prasanta Kumar Mitra*

Abstract

Role ofAmaranthusspinosusLinn.in indomethacin induced gastric ulcers was studied in rats. Amaranthusspinosus Linn. Leaves significantly reduced ulcer index induced byindomethacin. The plant leaves produced gastric anti secretory effect by decreasing gastric volume and acidity. It further increased gastric mucin which showedgastric cytoprotective effect. The plant prevented the increased lipid peroxidation during ulceration by indomethacin. Activities of the anti oxidant enzymes were enhanced during ulceration by this plant leaves. Results were comparable to that of ranitidine, a standard anti ulcer drug.Anti ulcerogenic activity of Amaranthusspinosus Linn. leaveswas, thus, mediated through anti oxidant defense mechanism.

Keywords: AmaranthusspinosusLinn, indomethacin, ranitidine, gastric ulcer, SOD, CAT, GSH.