Abstract

DESIGN OF CONTROL RELEASE OSMOTIC DRUG DELIVERY SYSTEM: A REVIEW

Saroj Jain, Rashmi Sharma

Abstract

The development of an ideal drug delivery system providing constant release of drug has been focus of much research, mainly with the objective of providing constant drug delivery during passage the GIT irrespective of variation in pH, surface tension, and viscosity as well as motility of GIT. Osmotic controlled drug delivery system is not influenced by different physiological factors with in the gut lumen and the release characteristic can be predicted easily from the drug and dosage form. Good product performance in osmotic system includes permeability of coating and drug release from the system. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. Osmotic pumps release drug at a rate that is independent of pH and hydrodynamics of the dissolution medium. The historical development of osmotic systems includes development of Rose-Nelson pump, Higuchi- Leeper pumps, Alzet and Osmet systems, elementary osmotic pump, and push-pull system applicability map and controlled porosity osmotic pump. This paper highlights the principle of osmosis, materials used for fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system.

Keywords: Osmosis, osmotic pressure, osmogen, semi permeable membrane,Osmotic pump, controlled-porosity osmotic pump tablet.