Abstract

PRINCIPLES OF DRUG RELEASE IN VARIOUS DOSAGE FORMS

K.Venkata Ramana Reddy, Dr. B. Venkateswara Reddy2, P.Shruti

Abstract

Among various dosage forms parenteral dosage form stands in first place to exert its action in individuals and next to this in current day‟s aerosol and nasal dosage forms competent to parenteral route. Drug release may follow mixed mechanism of release; it may involve both diffusion and dissolution controlled processes. The drug release is function of excipients, in which the drug is embedded or covalently bound. type of excipients, their concentration, method of manufacturing, physico-chemical properties of drugs and excipients, design of dosage form (geometry), routes of administration, pharmacokinetic and physico-dynamic parameters of drug. Morphological characteristics such as porosity, tortuosity, surface area, and shape of the system. Hydrophilicity/hydrophobicity of the system, chemical interaction between drug and polymer, polymer characteristics such as glass transition temperature and molecular weight .It is not always correct to show the same type of release in all dosage forms with same excipients and is going to vary and depend upon release the all above parameters to subject optimization.

Keywords: Physico-Chemical Properties of Drug and Excipients, Various Dosage Forms