Abstract

IN VITRO CYTOTOXICITY AND CELL VIABILITY ASSAY OF CORIANDRUM SATIVUM L. SEED POWDER EXTRACTS

Swetha M. and Krithika N.*

Abstract

The anticancer activities of aqueous and ethanol seed powder extracts of Coriandrum sativum L. was investigated in vitro by MTT assay on human breast adenocarcinoma cell lines (MCF-7). Cells were exposed to various concentrations of both extracts for 72 hours. The percent cell viability increased with increase in concentration of the plant seed extracts after addition. The MTT assay evinced that both aqueous and ethanol seed powder extracts of C. sativum L. exhibited the in vitro cytotoxicity on MCF-7 human cell lines. The inhibition of cancer cell growth was highest in the 500 μg/mL concentration. The IC 50 values were better in the ethanol extract than in aqueous. It also induced cell death in MCF-7 cells. These results indicate that Coriandrum sativum L. seed powder extract could be used as potent anticancer natural medicine and could lead to drug formulation.

Keywords: Anticancer, Coriandrum, Cytotoxicity, MCF-7, MTT.