Abstract

SYNTHESIS OF COUMARIN AND THEIR DERIVATIVES WITH THEIR APPLICATINS BY DIFFERENT METHODS

Shilpa V. Narale*

Abstract

Coumarin is a natural product obtained from mullein (Verbascum spp.), sweet grass (Hierochloe odorata), cassia cinnamon (Cinnamomum cassia) tonka bean (Dipteryx odorata), vanilla grass (Anthoxanthum odoratum) and sweet wood ruff (Galium odoratum). Coumarins are classified as a member of the benzopyrone family all of which consist of benzene ring joined to pyrone ring. The benzopyrones can be classified into the benzo alpha-pyrones to which the coumarins belong and the benzo gamma-pyrones of which the flavonoids are principal members. Umbliferone, esculetin and scopoletin are the most widespread coumarins in nature. During the synthesis of these compounds ortho-hydroxylation should respectively takes place on p-coumaric, caffeic and ferulic acid. The coumarins are of great interest due to their pharmalogical properties. In particular their physiological, bacteriostatic and anti tumor activity make these compounds attractive backbone derivatisation and screening as novel therapeutic agents. It also shows anti-HIV, anti-fungal, and anti-cancer activity. Coumarins are nowadays an important group of organic compounds that are used as additives to food and cosmetics, optical brightening agents, and dispersed fluorescent and laser dyes. The derivatives of coumarin usually occur as secondary metabolites present in seeds, root, and leaves of many plant species.

Keywords: Coumarin is a natural leaves of many plant species.