Abstract

IDENTIFICATION & SCREENING OF NSSNP’S FOR HYPERTHYROIDISM & PERFORMING MODELLING & DOCKING STUDIES ON NSSNP’S CODING PROTEIN OF HYPERTHYROIDISM

Jyothi J S, Anitha P M, Kusum Paul

Abstract

Hyperthyroidism, commonly known as overactive thyroid, occurs mainly because of the presence of thyroid hormone in the bloodstream in an abnormal way. The thyroid hormones are found in the thyroid gland, which is located in the neck. Graves disease, Toxic thyroid adenoma and Toxic Multi nodular goiter are some of the other reasons causing hyperthyroidism. Hyperthyroidism is characterized by the symptoms such as nervousness, irritability, increased perspiration, hand tremors, anxiety and muscular weakness. Genetic variation and Single nucleotide polymorphisms (SNPs) analysis will be an effective approach to understand the molecular mechanism involved in hyperthyroidism in an enhanced way. In our work, we identified genetic variations followed by SNPs to investigate the genes involved in hyperthyroidism, so as to obtain the target genes. The genetic variation and SNPs identification fetched us C1QTNF6 as a target gene. There was need to find the structural information for C1QTNF6 genes, Modeller tool was used to serve this purpose. Finally, modelled structure was validated, followed by docking studies to analyze interaction between target protein and lead molecules.

Keywords: Hyperthyroidism, Genetic variation, non-synonymous SNPs.