Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CANTHIUM DICOCCUM ON AZITHROMYSIN INDUCED HEPATOTOXICITY

Kiranmai G.* and Veena Rani I.

Abstract

There is a lack of consistent hepatoprotective drugs in contemporary medicine to treat drug-induced liver damage. The aim of the present study was to evaluate hepatoprotective activity of ethanolic extract of Canthium dicoccum. Albino rats (150–200 g) were separated into five groups. Groups I, II were normal (2% Tween 80) and toxic controls (Azithromycin 11.2 mg/kg. p.o), respectively. Groups III served as standard control (sylimarin), IV and V received the ethanolic extract of Canthium dicoccum 200 mg/kg and 400 mg/kg respectively for 7 days. Hepatotoxicity was induced in Groups II, III, IV and V by Azithromycin (11.2 mg/kg. p.o) twice for 7 days. The hepatoprotective effect was evaluated by physical parameters like wet liver weight and wet liver volume and biochemical parameters like SGOT, SGPT, ALP and bilirubin were estimated by autoanalyser with standard kits. The assay results were presented as mean and standard error of mean (SEM) for each group. In groups III, IV and IV, liver enzymes and albumin globulin ratio were significantly (P < 0.01) closer to normal. Histopathological examination revealed reduction in sinusoidal congestion, gloomy swelling and fatty changes and regenerative areas of the liver in groups III, IV and IV. These findings revealed that the Canthium dicoccum ethanolic extract has significant hepatoprotective activity.

Keywords: Hepatoprotective, hepatotoxicity, Canthium dicoccum, Azithromycin, silymarin