Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL CHALCONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

A. Asrar Ahamed*, M. Mohamed Sihabudeen, M. Syed Ali and M. Syed Abuthakir

Abstract

A series of chalcones was synthesized using Claisen- Schmidt condensation reaction by acetanilide with formyl morphiline. The resulting chalcones after purification have been converted into pyrazoline by reaction with hydrazine hydrate and isoniazid. All the products were tested for purity by TLC and characterized by elemental analysis (for carbon, hydrogen and nitrogen), IR, 1H-NMR and 13CNMR spectral studies. The synthesized compounds have been screened for their anti-inflammatory activity against both In-vitro and In-silico studies gives a significant activity as compared to standard.

Keywords: Chalcones, isoniazid, Pyrazolines, anti-inflammatory activity and docking studies.