Abstract

BIOMEDICAL APPLICATIONS OF CHITOSAN-SALICYLALDEHYDE SCHIFF BASE/ POLYPROPYLENE GLYCOL BLEND

S. Manju, C. Bhuvaneswari, R. Bharathi Priyadarshini and K. Vijayalakshmi*

Abstract

The present research work deals with the synthesis and characterization of chitosan-salicylaldehyde Schiff base/polypropylene glycol blend. Advanced analytical techniques such as FT-IR, XRD, TGA and SEM studies were employed to characterize the prepared samples. The obtained FT-IR results clearly shows the formation of Schiff base (C=N) linkage in chitosan and in addition the appearance of new peaks also suggested that the polypropylene glycol gets effectively binded with the chitosan schiff base. The XRD and TGA studies indicate the amorphous nature and the enhanced thermal behavior of blended Schiff base sample. The scanning electron microscopic (SEM) studies of the prepared chitosan Schiff base/polypropylene glycol blend showed the microporous structure with rough surface morphology. Evaluation was done to test the antimicrobial potential of the synthesized chitosan salicylaldehyde Schiff base/polypropylene glycol blend against three bacterial species namely Bascillus subtilis, E. coli and pseudomonas and against three fungal species namely Aspergillus flavus, penicillium notatum and Rhizopus nigricans respectively. From the obtained higher zone of inhibition values, it was evident that the chitosan-salicylaldehyde Schiff base/polypropylene glycol blend has the very good antimicrobial behavior and hence this chitosan-salicylaldehyde Schiff base/polypropylene glycol blend was found to be suggested as the promising material for biomedical applications.

Keywords: Chitosan, salicyalaldehyde, Schiff base, polypropylene glycol, antibacterial, antifungal.