Abstract

ELECTROPHILIC AND FREE RADICAL BROMINATION OF BIOLOGICALLY ACTIVE BROMO DERIVATIVES OF [B] CARBAZOLE USING NBS/ H2SO4.

M. Sathiya and S. Guhanathan*

Abstract

The prevalence of heterocycles in medicinally important compounds continues to derive the need for new methods for their preparation. Carbazole derivatives are known to have important biological properties. 2,7-dibromo-1,2,3,4-tetrahydrocarbazole A was prepared in good yield by an electrophilic bromination using NBS/ con.H2SO4. Compound B was prepared by free radical bromination method to yield 2,6-dibromo-1,2,3,4-tetrahydrocarbazole. The synthesized compounds were characterized and confirmed by FTIR, 1H NMR, 13C NMR and Mass spectroscopy. The synthesized compounds were carried out under antibacterial evaluation. The results showed that the synthesized compounds exhibit good antibacterial activity.

Keywords: 2,6-dibromo-1,2,3,4-tetrahydrocarbazole, N-bromo succinimide, con. Sulphuric acid, ciprofloxacin, 1,2,3,4-tetrahydrocarbazole.