Abstract

BIOLOGICAL ACTIVITIES OF SCHIFF BASES AND THEIR COPPER (II) COMPLEXES

N. Khathijathul Kubra, A. Suganya, J. Saranya* and S. Santha Lakshmi

Abstract

Coordination Chemistry occupies a larger area of inorganic research. Generally coordination complexes are formed through chemical bond called coordination bond formed between a metal atom or ion and a molecule with one or more unshared electron pairs, called a ligand. Schiff base is one of the significant ligand in the field of coordination chemistry research. Schiff bases can be prepared by condensing carbonyl compounds and amines in different conditions and in different solvents with the elimination of water molecules. Schiff base ligands are able to coordinate many metal ions and stabilize them in various oxidation states. Among the various metal complexes, Schiff base copper metal complexes exhibits enormous biological properties like antibacterial, antifungal and larvicidal activity. This study deals the synthesis of two Schiff base metal complexes (complex 1 and complex 2) with the general formula [Cu(II)L1L2] In complex 1(where L1 = Schiff base derived from 2,6 diamino pyridine with ohydroxy benzaldehyde, L2 = L-cysteine) and in complex 2 (where L1= Schiff base derived from L-histidine with vanillin, L2 = 2,6 diamino pyridine). Formation of imine moiety in complex 1 and complex 2 was confirmed by FTIR spectra. Antioxidant and larvicidal activity were carried out for the prepared Schiff base ligand and its metal complexes which confirms the scavenging and mortality activity.

Keywords: Schiff base copper metal complexes, Antioxidant and Larvicidal activity.