Abstract

SYNTHESIS AND CHARACTERISATION OF Î’-CYCLODEXTRIN AND HYDROXYAPATITE COMPOSITE BY ULTRASONICATION METHOD

G. Gowri and P. N. Sudha*

Abstract

Cyclodextrins (CDs) are one of the most versatile substances produced by nature, and it is in the aqueous biological environment where the multifaceted potential of CDs can be completely unveiled. Cyclodextrins form inclusion complexes with a variety of guest molecules, including polymers, producing very diverse biocompatible supramolecular structures. Among the polymeric biomaterials, hydroxyapatite plays an important role by possessing biomedical applications. In the present work, we have synthesized two component composite system incorporating β-cyclodextrin with hydroxyapatite by simple ultrasonication method in order to produce inclusion complexes of β-cyclodextrin. The binary composite has been characterised by using Fourier transform infrared spectroscopy (FT-IR) and Thermo gravimetric analysis (TGA) technique. Using this technique, we have concluded that intermolecular interactions between the two components and also thermal stability of the prepared sample.

Keywords: ?-cyclodextrin, biomaterial, hydroxyapatite, inclusion complex.