Abstract

SYNTHESIS, CHARACTERIZATION, DNA BINDING AND ANTIMICROBIAL ACTIVITY OF TRIDENTATE SCHIFF BASE LIGAND AND ITS COBALT(II) COMPLEXES

G. Sasikumar, T. N. Balaji and A. K. Ibrahim Sheriff*

Abstract

New unsymmetrical tridentate Schiff base ligands and Cobalt(II) complexes were synthesized using 2-amino-3-hydroxypyridine, 2- aminophenol and 2-hydroxy-1-naphthaldehyde. The synthesized ligands and their Cobalt(II) complexes were characterized by using FT-IR, 1H NMR,13C NMR and UV-vis spectroscopic techniques. The infrared and electronic transition studies showed that the ligands are tridentate via the imine nitrogen and the phenolic oxygen atoms in a planar configuration. Binding interactions of the complexes with calf thymus DNA have been investigated by absorption spectrophotometer. The complexes were screened for their antibacterial and antifungal activity by disc diffusion method. The results of these studies showed that the metal complexes are more effective against selected antibacterial and antifungal pathogens as compared with Cobaltous chloride.

Keywords: Schiff base, Cobalt(II), Antibacterial activity, DNA Binding.