Abstract

CLINICAL APPROACH TO DIAGNOSIS & UPDATE ON CURRENT TARGETED THERAPIES: SYSTEMIC LUPUS ERYTHEMATOSUS

Asheena Asharaf V.V., Anjitha P., Jincy T.C., Aswathi K., Suresh A. and Venkatesh S.*

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Abstract

Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers and hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogeneous, reflecting the complex mosaic of disrupted molecular pathways converging into the SLE clinical phenotype. The SLE complex pathogenesis involves multiple cellular components of the innate and immune system, presence of auto antibodies and immune-complex, engagement of the complement system, dysregulation of several cytokines including type I interferons, and disruption of the clearance of nucleic acids after cell death. Use of immunomodulators and immunosuppre the natural course of SLE. In addition, morbidity and mortality in SLE not only derive from direct immune mediated tissue damage but also from SLE and treatment associated complications such as accelerated coronary artery disease and increased infection risk.

Keywords: Systemic lupus erythematosus, Epidemology, Diagnosis, Management.